Instruments and Solutions to Drive Therapeutic Antibody Development: An Interactive Infographic
Written By: Damon Anderson, PhD
Sep 09, 2024
Biologic drugs including monoclonal, bispecific, and fragment-based antibodies are produced from living host cells and are engineered to target cells involved in cancer, autoimmune disorders, and infectious diseases among others. The therapeutic antibody development process can be broken into two main workflows—Molecule Development and Cell Line Development.
Molecule Development focuses on the initial identification, characterization, and optimization of antibodies or antibody derivatives. Various techniques are used to identify the molecular target and screen large libraries to select the most promising hits. These leads are then refined to improve therapeutic properties like affinity, specificity, and efficacy.
Cell Line Development aims to establish a stable and productive cell line that can reliably produce the optimized antibody. The best performing cell line is subsequently optimized and used to establish the cell bank which serves as the main production engine for therapeutic manufacturing.
This interactive infographic takes a closer look at these two workflows focusing on Sartorius instruments, solutions, and services available to drive successful therapeutic discovery and production.Image: CellCollector Flex from Sartorius