Thermo Fisher Scientific DNAPac RP Semi-preparative Columns

Thermo Fisher Scientific introduces the Thermo Scientific™ DNAPac™ RP semi-preparative columns, designed to support advanced research and production in DNA and RNA oligonucleotide therapies. These columns feature 4 µm divinylbenzene (DVB) particles, optimized for precise separations and high-efficiency purifications across a wide range of conditions.

Key Features:

• Particle Size and Composition: The columns utilize 4 µm DVB particles with a super-macroporous structure, providing superior resolution and efficient separation for both short and long single- and double-stranded nucleic acids.
• Operating Range: The DNAPac RP columns support a wide pH range (0-14) and high temperatures (up to 110 °C), making them versatile for various method development needs.
• Scalability: Available in semi-preparative formats, these columns facilitate the transition from analytical to preparative scale, essential for labs developing and producing oligonucleotides.

Applications:

• Synthetic Oligonucleotides: Suitable for the purification of synthetic oligonucleotides, including siRNA, antisense oligonucleotides (ASO), and mRNA.
• Precision Medicine: Ideal for research in precision medicine where high-purity oligonucleotides are critical.

Performance:

• High Performance: The unique chemistry of the DNAPac RP columns ensures unmatched performance, with precise separations and sample purification under various pH and temperature conditions.
• Compatibility: The columns' ability to handle a broad range of mobile phase compositions enhances their compatibility with different analytical setups.